Evaluation of imaging protocol for ECT based on CS image reconstruction algorithm

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ZHOU Xiao-Lin, YUN Ming-Kai, CAO Xue-Xiang, LIU Shuang-Quan, WANG Lu, HUANG Xian-Chao and WEI Long. Evaluation of imaging protocol for ECT based on CS image reconstruction algorithm[J]. Chinese Physics C, 2014, 38(4): 048201. doi: 10.1088/1674-1137/38/4/048201
ZHOU Xiao-Lin, YUN Ming-Kai, CAO Xue-Xiang, LIU Shuang-Quan, WANG Lu, HUANG Xian-Chao and WEI Long. Evaluation of imaging protocol for ECT based on CS image reconstruction algorithm[J]. Chinese Physics C, 2014, 38(4): 048201.  doi: 10.1088/1674-1137/38/4/048201 shu
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Received: 2013-06-28
Revised: 2013-11-20
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Evaluation of imaging protocol for ECT based on CS image reconstruction algorithm

    Corresponding author: WEI Long,

Abstract: Single-photon emission computerized tomography and positron emission tomography are essential medical imaging tools, for which the sampling angle number and scan time should be carefully chosen to give a good compromise between image quality and radiopharmaceutical dose. In this study, the image quality of different acquisition protocols was evaluated via varied angle number and count number per angle with Monte Carlo simulation data. It was shown that, when similar imaging counts were used, the factor of acquisition counts was more important than that of the sampling number in emission computerized tomography. To further reduce the activity requirement and the scan duration, an iterative image reconstruction algorithm for limited-view and low-dose tomography based on compressed sensing theory has been developed. The total variation regulation was added to the reconstruction process to improve the signal to noise Ratio and reduce artifacts caused by the limited angle sampling. Maximization of the maximum likelihood of the estimated image and the measured data and minimization of the total variation of the image are alternatively implemented. By using this advanced algorithm, the reconstruction process is able to achieve image quality matching or exceed that of normal scans with only half of the injection radiopharmaceutical dose.

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