Small-angle X-ray scattering probe of intermolecularinteraction in red blood cells

LIU Guan-Fen; WANG We-Jia; XU Jia-Hua; DONG Yu-Hui

doi:10.1088/1674-1137/39/3/038001

Chinese Physics C> 2015, Vol. 39> Issue(3) : 038001 DOI: 10.1088/1674-1137/39/3/038001

Small-angle X-ray scattering probe of intermolecularinteraction in red blood cells

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Abstract：
With high concentrations of hemoglobin (Hb) in red blood cells, self-interactions among these molecules could increase the propensities of their polymerization and aggregation. In the present work, high concentration Hb in solution and red blood cells were analyzed by small-angle X-ray scattering. Calculation of the effective structure factor indicates that the interaction of Hb molecules is the same when they are crowded together in both the cell and physiological saline. The Hb molecules stay individual without the formation of aggregates and clusters in cells.

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LIU Guan-Fen, WANG We-Jia, XU Jia-Hua and DONG Yu-Hui. Small-angle X-ray scattering probe of intermolecularinteraction in red blood cells[J]. Chinese Physics C, 2015, 39(3): 038001. doi: 10.1088/1674-1137/39/3/038001

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Received: 2014-04-07
Revised: 2014-08-12

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