Characteristics of a heavy water photoneutron source in boron neutron capture therapy

Danial Salehi; Dariush Sardari; Salehi Jozani

doi:10.1088/1674-1137/37/7/078201

Chinese Physics C> 2013, Vol. 37> Issue(7) : 078201 DOI: 10.1088/1674-1137/37/7/078201

Characteristics of a heavy water photoneutron source in boron neutron capture therapy

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Abstract：
Bremsstrahlung photon beams produced by medical linear accelerators are currently the most commonly used method of radiation therapy for cancerous tumors. Photons with energies greater than 8-10 MeV potentially generate neutrons through photonuclear interactions in the accelerator's treatment head, patient's body, and treatment room ambient. Electrons impinging on a heavy target generate a cascade shower of bremsstrahlung photons, the energy spectrum of which shows an end point equal to the electron beam energy. By varying the target thickness, an optimum thickness exists for which, at the given electron energy, maximum photon flux is achievable. If a source of high-energy photons i.e. bremsstrahlung, is conveniently directed to a suitable D₂O target, a novel approach for production of an acceptable flux of filterable photoneturons for boron neutron capture therapy (BNCT) application is possible. This study consists of two parts. 1. Comparison and assessment of deuterium photonuclear cross section data. 2. Evaluation of the heavy water photonuclear source.

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[1]

Auditore L et al. Design of a Photoneutron Source Based on a 5 MeV Electron Linac Proceedings of EPAC 2004. Lucerne, Switzerland[2] Petwal V C. Pram. Jour. of Phys., 2007, 68(2): 235-241[3] Jong Kyung Kim, Kyung-O Kim. Nucl. Eng. Tech., 2009, 41(4): 531[4] Leanna R. Eller. An Investigation on Photoneutron Production from Medical Linear Accelerators (M. S. Thesis). Oregon State University, 2012 (in USA)[5] Zanini A et al. Phys. Med. Biol., 2004, 49: 571-582[6] LIU J C et al. Calculations of Photoneutrons from Varian Clinac Accelerators and Their Transmissions in Materials. Presented at Radiation Dosimetry and Safety. Taipei, 1997. SLAC-PUB-7404[7] Chilton A B, Shultis J K, Faw R. Principle of Radiation Shielding. Prentice Hall, Englewood Cliffs, New Jersey, 1984. ISBN 0-13-709907X[8] Gallmeier F X. General Purpose Photoneutron Production in MCNP4. ORNL/TM-13073. United States Department of Energy, 1995[9] Hannah E. Mitchell. An Accelerator-Based Epithermal Photoneutron Source for Boron Neutron Capture Therapy. (Ph. D. Thesis). Georgia Institute of Technology, April 1996. INEL-96/0212[10] International Atomic Energy Agency (IAEA) Handbook on Photonuclear Data for Applications Cross-Section and Spectra 1996-1999[11] Partiov F. Amm. Phys., 1964, 27: 79[12] Hamidi S, Scott M C. Nucl. Instrum. Methods in Phys. Research A, 2002, 476: 99-105[13] Reda M A, Harmon J F. A Photo neutron Source for Bulk Material Studies, Accepted to be Published in Advances in X-ray Analysis, Vol. 47, Proceedings of the 52nd Ann' Denver X-ray Conf', Denver, Colorado, 2004[14] David W. Nigg. In: Neutron Sources and Applications in Radiotherapy - A Brief History and Current Trends. 12th Int' Symp' Neu' Capt' Ther' U.S.A. Idaho. 2006

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Danial Salehi, Dariush Sardari and Salehi Jozani. Characteristics of a heavy water photoneutron source in boron neutron capture therapy[J]. Chinese Physics C, 2013, 37(7): 078201. doi: 10.1088/1674-1137/37/7/078201

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Received: 2012-08-31
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

Characteristics of a heavy water photoneutron source in boron neutron capture therapy

Corresponding author: Danial Salehi,

Received Date: 2012-08-31

Accepted Date: 1900-01-01

Available Online: 2013-07-05

Abstract: Bremsstrahlung photon beams produced by medical linear accelerators are currently the most commonly used method of radiation therapy for cancerous tumors. Photons with energies greater than 8-10 MeV potentially generate neutrons through photonuclear interactions in the accelerator's treatment head, patient's body, and treatment room ambient. Electrons impinging on a heavy target generate a cascade shower of bremsstrahlung photons, the energy spectrum of which shows an end point equal to the electron beam energy. By varying the target thickness, an optimum thickness exists for which, at the given electron energy, maximum photon flux is achievable. If a source of high-energy photons i.e. bremsstrahlung, is conveniently directed to a suitable D₂O target, a novel approach for production of an acceptable flux of filterable photoneturons for boron neutron capture therapy (BNCT) application is possible. This study consists of two parts. 1. Comparison and assessment of deuterium photonuclear cross section data. 2. Evaluation of the heavy water photonuclear source.

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Characteristics of a heavy water photoneutron source in boron neutron capture therapy

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